CARL JOHAN B. SUNDBERG, M.D., Ph.D.
General
Born:November 29, 1958, Stockholm, Sweden
Married:1985, 3 c
Residence:Linnévägen 26
184 51 Österskär, Sweden
Phone: +46-8 540 208 71
Work address 1:Dpt of Physiology & Pharmacology/Centre for Medical Innovations
Karolinska Institutet
S-171 77 STOCKHOLM, Sweden
Work address 2:Karolinska Investment Fund
Nobels Väg 15 A
171 77 STOCKHOLM, Sweden
Phone: +46-8 5248 68 86; fax: +46-8 5088 4459
E-mail: Carl.J.Sundberg@cmi.ki.se
Education and academic history
Dec 99Docent (Associate Professor)
March 97Registered/Licenced Physician (Läkarlegitimation)
Dec 93Dissertation for Dr. Med. Sc. (Ph.D.)
Jan 87Completed FMGEMS arranged by ECFMG (Educational Commission for Foreign Medical Graduates, USA) (Equiv. to National Board examinations)
Jan 86M.D. (Läkarexamen)
June 78Studentexamen, Östermalms Gymnasium, Stockholm, Sweden
July 77High School Diploma, New Canaan, Conn., USA
Professional positions and appointments
July 99-Investment manager (part time) at the Karolinska Investment Fund, a 600 MSEK biomedical VC-fund
Oct 98-Project leader (part time) at the Centre for Medical Innovations, Karolinska Institutet, focus on Bioentrepreneurship, science policy
April 97-Position as researcher at the Department of Physiology & Pharmacology, Karolinska Institutet.
Feb 94-March 97Position as research intern at Karolinska Hospital and Karolinska Institute (time divided between research and clinical periods in general, vascular and orthopedic surgery, anesthesiology, internal medicine, cardiology, psychiatry and family medicine.
June 92-Dec 93Position as graduate student (Doktorandtjänst) at the Department of Physiology & Pharmacology, Karolinska Institutet on the Swedish Space Board Program.
March 86-June 92Research associate graduate student at the Department of Environmental Physiology, Karolinska Institutet on the Swedish Space Board Program.
1984-86Clinical work, Family Medicine and Radiology (part-time).
Military service
April-May 88Diving physician training.
March-April 87War surgery training.
1978-79Basic Military service (Kustjägarskolan, the Marines).
Leadership experience & Strategic initiatives
1990-presentlyNumerous assignments on university committees (chairman or member),
Chairman Venture Cup East (a business plan competition involving 10 universities),
Chairman Senior Advisory Board of Connect Biomedical Partnership Forum, President Swedish Society for Sports Medicine,
Scientific secretary on Parliamentary Commission,
Mentor in structured programs,
Vice President Governing Board Euroscience (a pan-European Society promoting Science & Technology),
Initiator and Steering Committee Chairman of Euroscience Open Forum 2004,
a large biennial European meeting on Science & Technology (www.esof2004.org)
Business/Industry assignments
1986-presentlyBoard member of and adviser to several biotech/biomedical companies & industry organisations.
CEO and marketing director for biomedical education and business consultant companies.
Investment Manager in 65 M€ biomedical VC-fund.
Science
1986-presentlyResearch focus: Molecular mechanisms involved in the adaptation in human skeletal muscle to physical activity. Several national & international collaborations, 40 publications and reports, 5 PhD students, 3 post-docs, funding from industry & public sources. Also, experience as grant application evaluator (national, EU, NZ, Norway, Denmark, Italy, World Antidoping Agency ), journal referee, scientific secretary in scientfic society and PhD graduation committee member several times. Regularly invited speaker to national and international conferences. Editor, the Swedish Medical Journal (Läkartidningen) with responsibility for basic biomedical sciences.
Education, popular science & media
1984-presentlyExtensive experience of teaching, course creation, design and directorship in courses such as Physiology for Medical Students, Science Based Companies, Medicine for Medical Journalists, Popular Science Communication, Medicine for Science Teachers, Drug Discovery for the Financial Industry and Medicine for Decision Makers. Has created three major science centre exhibitions. Working periods in Swedish and US media (approximately 20 popular science articles). Recipient of the Karolinska Institutet Prize for Teaching Excellence (1998), a Certificate of Commendation for Communication in the Life Sciences from the European Molecular Biology Organization (2003) and Angpanneföreningen's prize for research communication (2005).
Recent invited lectures
Jan 05Basic research and the future European Research Council. Invited expert and speaker at a Public Hearing for the Committee on Industry, Research and Energy of the European Parliament, Brussels, 24 January 2005. General Theme: Science and Technology, the key to Europe's future, Future EU Policy to support Research, approximately 30 parliamentarians and over 200 other participants.
Nov 04Euroscience Open Forum – a novel European platform for an open and independent dialogue on science. In the symposium Scientific Culture & Society – need for political action. At ECSITE 2004 in Barcelona.
Oct 04Bioscientific industry as a strategic opportunity; knowledge and entrepreneurship. At a symposium organised by Fondacion Saluda Innovacion Sociedad, Barcelona Oct 04 Karolinska Institutet’s Innovation System. Presentation for the British Minister of Innovation, Science and Education.
Aug 04Moderated a plenary presentation entitled Can Europe compete in pharmaceutical research and development? by Didier de Chaffoy de Courcelles, Head of R&D at Johnson & Johnson, Europe.
May 04Genes, training & health. At the Swedish Cardiovascular Society Spring Meeting, Gothenburg.
March 04Regulation of gene expression. In the symposium Activation of genes in training and detraining (chairman) At the 7th Scandinavian Conference on Medicine and Science in Sports in Stockholm.
March 04Gene doping – where do we stand? In the symposium Doping - has testing caught up with the cheaters? At the 7th Scandinavian Conference on Medicine and Science in Sports in Stockholm.
Dec 03From Discovery to Sustainable Biotech Business – the Karolinska Model, at Cordia EuropaBio Convention 2003 in Vienna.
Sep 03The role of the scientist in popular science communication – more than to just answer questions? At the Book- & Library Fair, Gothenburg, Sweden.
Sep 03From Discovery to Sustainable Biotech Business – the Karolinska Model. At the Estonian Biotechnology Associations Annual Meeting in Tartu, Estonia.
June 03The role of Academia in the Formation of Life Science Start-ups- the Karolinska Institutet model, at the BIO 2300 Annual Convention, Washington DC, the world’s largest biotech industry meeting attracting 15-20.000 people.
April 03Molecular mechanisms and training adaptation. At the Friday Seminar, Salk Institute, La Jolla,
Dec 02Catching the Attention of VCs and Industrial Partners. At a meeting arranged by Kalmar BioScience and Connect, Kalmar, Sweden
Nov 02Gene expression in human skeletal muscle – can gene doping be detected? At the Swedish Medical Society Annual meeting, Gothenburg.
Nov 02Organised and chaired a round table discussion at “European Research 2002, The European Research Area and the Framework Programme”, in Brussels. Title: Medical Messages in the Media: Are well educated journalists better off (while trying to reach the big audience) – or just another endangered species?
Oct 02Genes, training & performance. At a conference on gene doping arranged by the Swedish Gene Technology Board.
Aug 02The Swedish Biotech Industry in an International Perspecitive (moderator) organized by SNS - Center for Business and Policy Studies. Among the speakers were biotech industry leaders, academic researchers and the Swedish Minister for Education and Research.
April 02Physical activity, genes & health. At CERN, Geneva, the Staff Association of CERN and Euroscience Lac Leman.
April 02The future innovation environment in Stockholm, panel debate
April 02Technology Transfer at Karolinska Institutet. At CERN, Geneva for the Technology Transfer group and for the faculty.
April 02Developing local deal flow. At an EU-conference in Stockholm on Regions of Innovation in Europe.
March 02Metabolism of exercising muscle. At the conference "Genetic Enhancement of Athletic Performance", arranged by World Anti-Doping Agency, at the Banbury Center, Cold Spring Harbor Laboratory, New York.
Feb 02Exercise induced gene expression in human skeletal muscle – why of interest to the pharmaceutical industry? Pfizer Central Research, Groton, Connecticut.
Graduate students & post-docs
1996-presentlyThomas Gustafsson, M.D.
1996-presentlyGöran Lundberg, M.D. Vascular Surgery.
1998-presentlyUlrika Berg, M.D., Pediatric endocrinology
2000-presentlyHelene Ameln, B Sc Molecular biology, 1 year Physiology
2001-presentlyJessica Bengtsson, B Sc Molecular biology, 1 year Physiology
Jan 2000-Dec 2001Myriam-Peyrard-Janvid, PhD
Jan-Aug 2001Ulrika Widegren, PhD
Jan 2003 -Helene Fischer, PhD
Sep 2003-Jamie Timmons, PhD
Selected publications
2005Gustafsson T, Ameln H, Fischer H, Sundberg CJ, Timmons JA & Jansson E. VEGF-A splice variants and related receptor expression in human skeletal muscle following submaximal exercise.J Appl Physiol. 2005 Jan 20; [Epub ahead of print]
2005Timmons, J.A., Larsson, O, Jansson, E., Fischer, H., Gustafsson, T., Greenhaff, P.L. Ridden, J., Rachman, J., Peyrard-Janvid, M., Sundberg, C.J. Human muscle gene expression responses to endurance exercise provide a novel perspective on Duchenne muscular dystrophy. FASEB J (Accepted) 2005
2005Helene Ameln1,2*, Thomas Gustafsson1,3*, Carl Johan Sundberg1, Lorenz Poellinger2, Eva Jansson3, Yuichi Makino2,4. Physiological Activation of Hypoxia Inducible Factor - 1 in Human Skeletal Muscle. Faseb J (final revision) 2005
2004Norrbom, J., Sundberg, C.J., Ameln, H., Kraus, W.E., Jansson, E. & Gustafsson, T. PGC-1 alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle. J Appl Physiol. 96(1):189-194, 2004
2004Timmons J. & Sundberg C.J. Determinants of human exercise performance (Letters to the editor), Physiology News Summer issue (55), 41-42, 2004.
2004Sundberg CJ, Ostenson CG, Stahle A. Human beings are made for physical activity! Physical activity as a cure against life style-diseases--a new series in LT (Swedish.). Läkartidningen (J Swe Med Assoc) 101(20):1776, 2004.
2003Henriksson J & Sundberg C.J. Biological effects of physical activity. In A Stahle (Ed): Physical activity in the prevention and treatment of disease, 412 pages. National Institute of Public health. (Pp 9-33) October 2003.
2002Milerad J, Ahlberg J, Eliasson M, Friden B, Hakansson A, Sundberg CJ, Agren H, Ostergren J. More stringent requirements concerning manuscripts. Declarations of potential connections and conflicts of interest published in the Lakartidningen (Article in Swedish). Lakartidningen 11;99(15):1662-3, Apr 2002
2002T. Gustafsson, A. Knutsson, A. Puntschart, L. Kaijser, A.-C. Sandberg Nordqvist, C. J. Sundberg, E. Jansson. Increased expression of vascular endothelial growth factor in human skeletal muscle in response to short-term one-legged exercise training. Pflügers Arch - Eur J of Physiol. Pp 1-17, July 2002.
2002Lundberg, G., Olofsson, P., Ungerstedt, U., Jansson, E. & Sundberg, C.J. Local skeletal muscle metabolism during constant load exercise at various degrees of blood flow restriction in healthy males Pflügers Arch - Eur J of Physiol, 443(3):458-465, 2002.
2001Bengtsson J, Gustafsson T, Widegren U, Jansson E, Sundberg C J. Mitochondrial transcription factor A and respiratory complex IV increase in response to exercise training in humans. Pflügers Arch - Eur J of Physiol, 443(1):61-6, 2001.
2000Gustafsson T, Sundberg CJ. Expression of angiogenic growth factors in human skeletal muscle in response to a singular bout of exercise. Am J Physiol Heart Circ Physiol. 279:H3144-5, 2000
1999Esbjörnsson-Liljedahl, M., C.J. Sundberg, B. Norman & E. Jansson. Metabolic response in type I and type II muscle fibers during a 30-s cycle sprint in men and women. J Appl Physiol 87(4):1326-32, 1999 Oct..
1999Gustafsson, T., Puntschart, A., Kaijser, L., Jansson, E. & Sundberg, C.J.. Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle. Am J Physiol 276 (Heart Circ Physiol 45): H679-H685, 1999.
1999Gustafsson, T., Puntschart, A., Sundberg, C.J. & Jansson. E. Related expression of vascular endothelial growth factor and hypoxia-inducible factor-1 mRNA in human skeletal muscle. Acta Physiol Scand 1999.
1998Timmons, J.A., T. Gustafsson, C.J. Sundberg, E. Jansson & P.L. Greenhaff. Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise. Am J Physiol. 274 (Endocrionol Metab 37), E377-E380, 1998.
1998Viru, M, Jansson, E, Viru, A & Sundberg, C.J. Effect of restricted blood flow on exercise induced hormonal changes in healthy males. Eur J Appl Physiol 77:517-522, 1998.
1998Timmons, J.A., T. Gustafsson, C.J. Sundberg, E. Jansson, E. Hultman, L. Kaijser, J. Chwalbinska-Moneta, D. Constantin-Teodosiu, I.A. Macdonald & P.L. Greenhaff. Substrate availability limits human skeletal muscle oxidative ATP regeneration at the onset of ischemic exercise. J Clin Invest 101:79-85, 1998.
1998Sundberg, C.J. & E. Jansson. Physical activity reduces morbidity and delays death (Review, Swedish). Läkartidningen (J Swe Med Assoc) 1998, 4062-4067, 1998.
1996Sundberg, C.J. Effects and side-effects of certain substances used for doping purposes and experiences of treatment - review of the scientific literature (Swedish). In: Doping in a Public Health Perspective. Report (SOU 1996:126) by the Commission on Doping to the Swedish Government. Part B, pp 5-138. October 3, 1996.
Articles outside scientific specialty
2004Degett, J & Sundberg, C.J. Euroscience Open Forum 2004 - debating the future of science in Europe. In: The ELSO Gazette under Feature. Issue 20, July 2004.
2004Sundberg, C.J. Knowledge-Building Through Science – An Issue For All Of Us. In: More than Science, Opinion-section, Sep 9, 2004.
2002Sundberg, C.J. & Connerade, J-P. Forums for Open Dialogue: fostering involvement in European Research. In: Special issue: European Academies: A Driving Force for the European Research Area, IPTS Report Vol 70, Dec 2002.