Theodor Bücher Lecture and Medal
July 3rd, Sunday, 08.30-09.20
Douglas B. Kell

dbk@umist.ac.uk
http://dbk.ch.umist.ac.uk/dbk.htm
CV
Education
  • 1966-1970 Secondary education: Bradfield College, Berkshire (Top Scholar)
    "A" Levels: Physics (A), Chemistry (A), Pure & Applied Mathematics (B).
  • 1975 B.A. (Hons) Biochemistry, St John's College, Oxford, Class 2-1, with Distinction in Chemical Pharmacology.
  • 1978 Senior Scholar of St John's College, Oxford. M.A. (Oxon).
  • 1978 D.Phil. (Oxon); thesis title: "The Bioenergetics of Paracoccus denitrificans".
Postdoctoral work
  • 1978-1980 SRC Postdoctoral Research Fellow, University College of Wales, Aberystwyth. Project title: "Energy Coupling in Methanogenic Bacteria".
  • 1980-1981 Postdoctoral Research Assistant, University College of Wales, Aberystwyth. Project title: "Butyricin 7423 and the membrane H+ATPase of Clostridium pasteurianum".
  • 1981-1983 SERC Advanced Fellow, University College of Wales, Aberystwyth. Project title: "Novel approaches to the understanding of protonmotive systems in bacteria".
  • 1983-1988 "New Blood" lecturer in Microbial Physiology, Department of Botany & Microbiology, University College of Wales, Aberystwyth.
  • 1988- Director, Aber Instruments Ltd
  • 1988-1992 Reader in Microbiology, Dept of Biological Sciences, University College of Wales, Aberystwyth.
  • 1992-2002 Personal Chair, University of Wales
  • 1997-2002 Director of Research, Institute of Biological Sciences, UW Aberystwyth.
  • 2001- Director, Aber Genomic Computing
  • 2002- EPSRC/RSC Research Chair in Bioanalytical Sciences, Dept of Chemistry, UMIST.
Awards and Distinctions
  • 1986 Recipient of the Fleming Award of the Society for General Microbiology, awarded annually by the Society "in recognition of outstanding research by a young microbiologist working in the UK or the Republic of Ireland".
  • 1986-1987 Co-recipient (with Dr R.W.Todd) of one of 12 SMART Awards (Phase I and Phase II) for novel instrumentation from the Department of Trade and Industry, for "the development of an electronic biomass probe".
  • 1989-1990 Co-recipient (with colleagues from Aber Instruments) of a SMART Award (Phase I and Phase II) from the Department of Trade and Industry for the development of "An automated bacterial colony counter".
  • 1999 Fellow of the Institute of Biology (CBiol FI Biol)
  • 2002 DTI Beacon Award in collaboration with Mike White (Liverpool University), Steve Oliver and Norman Paton (University of Manchester).
Research Interest
Exploiting advanced physical and computational methods to understand complex, biological systems, especially post-genomic systems and the use of metabolomics. These methods include mass and vibrational spectrometries.

We also have a substantial interest in the methods of evolutionary computing for attacking combinatorial optimisation problems.

Selected recent publications
  1. Kell, D.B. and Oliver, S.G. (2004)
    Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era.
    Bioessays 26, 99-105.
  2. King, R.D., Whelan, K.E., Jones, F.M., Reiser, P.G., Bryant, C.H., Muggleton, S.H., Kell, D.B. and Oliver, S.G. (2004)
    Functional genomic hypothesis generation and experimentation by a robot scientist.
    Nature 427, 247-252.
  3. Allen, J., Davey, H.M., Broadhurst, D., Heald, J.K., Rowland, J.J., Oliver, S.G. and Kell, D.B. (2003)
    High-throughput classification of yeast mutants for functional genomics using metabolic footprinting.
    Nature Biotechnol. 21, 692-696.
  4. Taylor, C.F., Paton, N.W., Garwood, K.L., Kirby, P.D., Stead, D.A., Yin, Z., Deutsch, E.W., Selway, L., Walker, J., Riba-Garcia, I., Mohammed, S., Deery, M.J., Howard, J.A., Dunkley, T., Aebersold, R., Kell, D.B., Lilley, K.S., Roepstorff, P., Yates, J.R. 3rd, Brass, A., Brown, A.J., Cash, P., Gaskell, S.J., Hubbard, S.J. and Oliver, S.G. (2003)
    A systematic approach to modeling, capturing, and disseminating proteomics experimental data.
    Nature Biotechnol. 21, 247-254.
  5. Kell, D.B. (2002)
    Genotype-phenotype mapping: genes as computer programs.
    Trends Genet. 18, 555-559.
  6. Raamsdonk, L.M., Teusink, B., Broadhurst, D., Zhang, N., Hayes, A., Walsh, M.C., Berden, J.A., Brindle, K.M., Kell, D.B., Rowland, J.J., Westerhoff, H.V., van Dam, K. and Oliver, S.G. (2001)
    A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations.
    Nature Biotechnol. 19, 45-50.